The CNS glucagon-like peptide-2 receptor in the control of energy balance and glucose
نویسنده
چکیده
Title: The CNS glucagon-like peptide-2 receptor in the control of energy balance and 1 glucose homeostasis 2 3 Xinfu Guan 4 USDA/ARS Children's Nutrition Research Center, Department of Pediatrics; Division 5 of Diabetes, Endocrinology & Metabolism, Department of Medicine, Baylor College of 6 Medicine, Houston, TX, USA 7 8 Running head: the CNS GLP-2 promotes glycemic control 9 Address for reprint requests and correspondence: Dr. Xinfu Guan can be reached at 10 [email protected], 713-798-9322 (phone), or 713-798-7101(fax). His mailing address: 11 Children's Nutrition Research Center, 1100 Bates St., Houston, TX 77030. 12 13 Grant Support: This work is supported by the USDA/ARS under Cooperative Agreement No. 14 6250-51000-049-02S-2 and 6250-51000-054-00D-3 (XG); NIH grants DK075489 and 15 DK084125 (XG); and NIH grant DK56338 (which supports the Texas Medical Center Digestive 16 Diseases Center). 17 18 Disclosures: The author has nothing to disclose. 19 20 Abbreviation: GLP-1/2: glucagon-like peptide-1/2; Glp2r (gene) or Glp2r (protein): GLP-2 21 receptor; Glp1r (gene) or Glp1r (protein): GLP-1 receptor; Mc4r (gene) or Mc4r (protein): 22 melanocortin receptor 4; LepR (gene) or LepR (protein): leptin receptor; InsR (gene) or InsR 23 (protein): insulin receptor; PI3K: phosphatidylinositol-3-kinase; CNS: central nervous system; 24 RYGB: Roux-en-Y gastric bypass; HGP: hepatic glucose production; FI: food intake; GE: 25 gastric emptying; GI: gastrointestinal; icv: intracerebroventricular; PPG: preproglucagonergic; 26 POMC: pro-opiomelanocortin; αMSH: α-Melanocyte-stimulating hormone; ARC: arcuate 27 nucleus of the hypothalamus; DMH: dorsomedial nucleus of the hypothalamus; NTS: nucleus 28 tractus solitarius in the brainstem; DMV: dorsal motor nucleus of the vagus; PBN: parabrachial 29 nucleus of the brainstem; DVC: dorsal vagal complex of the brainstem (including NTS plus 30 DMV) 31 Articles in PresS. Am J Physiol Regul Integr Comp Physiol (July 2, 2014). doi:10.1152/ajpregu.00096.2014
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The CNS glucagon-like peptide-2 receptor in the control of energy balance and glucose homeostasis.
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